What works for me is this:
1. In the Wineskin Screen Settings screen I select the options mentioned by AND at the beginning of this thread. See screen shot #1.
2. I run CF 2.5, it runs in a virtual screen and I close it.
3. I re-run Wineskin and in the Screen Settings screen I re-select "Automatic" in "Override ccontrol" and "Use Mac driver" in Other options. See screen shot #2.
And then CF 2.5 runs normally.