Adjusting Layers on a large frame with multiple rooms?

Hey guys the title basically says it all. I've talked about this a few times on the forums in different manners but is there any way you guys know how to pin layers to specific spots on a large frame? Like for example, the first section is outside and there are about 2 to 3 layers dedicated to background parallax. The 2nd section is inside of a building where you go up so just as vertical parallax is going on there, then its back outside again. Is there anyway to do this that doesnt 1) slow down frame rate and 2) really jack up the parallax. It would be much easier in my case to be able to build 1 massive level but if it affects the parallax badly i'll just skip on it. Also, i use the parallaxer object for clouds and such. Since its basically like a "follow the frame" object do you guys know a way around that as well? Hope this made some sense lol and sorry for novel.