Currently in the game I'm making, everything is pretty much twice the size than what it needs to be. My characters size for example is 32x32 and sometimes 32x64 (It's an active with LOTS of different animation). This is four times the amount of pixels that is needed as I could resize the character to a size of 16x16 / 16x32.
Performance wise, would it be better to rezise the object to 16x16 and then use the "set scale to 2 (quality = 0)"? Is the "set scale"-function CPU demanding?