Well, it's something that has been discussed for a while: https://community.clickteam.com/threads/109650-Att-Fernando-Samples-causing-lag
In my game, you control a character that use weapons, and enemies uses weapons too, there is an online matchmaking so, more weapons shooting at same time.
I get FPS drops everytime a sample is played (no issue with musics). Like if the game search for the sound, load it up then play it.
Also, how do you play sounds? In my case i use "play sample on specific channel", maybe this action use more memory?