First when you set up a new sprite ( using the Sprite>New Sprite... action ) you specify the number of directions and the number of animation frames per direction. The total number of frames will be the number of animation frames times the number of directions. Let's say you set up a new sprite with 4 directions and 2 animation frames per direction, the first two requested texture handles would be for the two animation frames for dir 0 ( facing right ), the next two requests will be for the animation frames of dir 1 ( facing camera ) and so on.
When you have created a new object ( Objects>Add Object... ) with the sprite you just set up you can animate it by simply calling the Object>Animation>Start... action. Important to note is that when the Animation Speed parameter is set to 1.0 the current animation frame will be updated each MMF frame loop. That is very fast so a more useful value would be somewhere between 0.0 and 1.0.
Let me know if anything is unclear.
I'll try it