Thanks @mickarrow . I use Toon Boom Harmony Premium for the animation in Spryke. Below are some snippets of what it looks like (the animation shown is a little rough around the edges, but you get the idea).
Toon Boom Harmony Premium isn't cheap, but I can't recommend it enough. It's got the most intuitive vector tools I've ever seen in any program (I create everything in vector but export into Fusion as raster), and I love how everything is controlled with a node hierarchy. You can see the node view in the 2nd gif. Spryke herself is comprised of 250+ nodes, but that probably looks and sounds more complicated than it is. In reality, it means that you can connect every piece of her in a logical and intuitive way. So, for example, if I move/scale/rotate her eyeball then her iris, pupil, and the little white reflection on her pupil will all automatically move with it...though I can also move any of those elements independently if I wish. So I only need to rig her once, and then I can reuse that rig for any number of different animations.